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Background and Objectives: Tinnitus is one of the most common complaints among patients in ENT and neurology clinics. Defined as the perception of phantom sounds originating in the head, it is estimated to affect about 20% of the population, with 1% experiencing severe symptoms that impact quality of life and can even lead to suicidal thoughts. Currently, there is no definitive test or universally accepted treatment for tinnitus, leaving healthcare providers to try various medications and protocols with each patient. This study investigates the effectiveness of clonazepam in managing tinnitus or at least mitigating its impact on patients’ quality of life.

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Methods: In this crossover study, 80 patients meeting the inclusion criteria and providing informed consent were randomly split into two groups. Group 1 received clonazepam for the first month, followed by a three-month assessment period using a specific survey. In the second stage, they switched to ginkgo biloba, a commonly used herbal remedy for tinnitus, for one month, with a subsequent two-week survey follow-up. Group 2 started with ginkgo biloba and then switched to clonazepam, allowing each patient to serve as their own control.

Results: Patients showed significant improvement with clonazepam (p < 0.05) based on both the Tinnitus Handicap Inventory (THI) and Visual Analog Scale (VAS), compared to their baseline status. No significant improvement was noted with ginkgo biloba (p > 0.05).

Conclusion: Clonazepam appears to be an effective treatment option for subjective tinnitus, irrespective of its severity or duration. The findings suggest reducing reliance on ginkgo biloba for tinnitus management. Background and Objectives

Tinnitus, like headaches or pain, is a symptom rather than a medical condition on its own. Individuals describe tinnitus in various ways, with sounds like ringing, buzzing, humming, or hissing being common. Studies from the British National Center for Diseases report that up to 96% of people experience tinnitus at some point, though only 20% develop chronic cases. Conditions like hearing loss and sound sensitivity are often associated with tinnitus.

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Currently, tinnitus lacks a precise definition and a reliable measurement method. It is generally defined as an auditory perception of phantom sounds without an external source. This study focuses on subjective tinnitus, which is perceived only by the patient and represents over 75% of tinnitus cases linked to ear-related issues, as opposed to objective tinnitus, where the sound source is physical and can sometimes be audible to others, such as blood circulation or muscle spasms in the ear.

Groups at highest risk for developing tinnitus issues include individuals exposed to loud noise from an early age or sudden, violent sounds causing ear trauma. Additionally, there is a noted link between age-related hearing loss (presbycusis) and tinnitus, with a prevalence rate of about 35% among those affected by presbycusis. NSAIDs are considered a reversible risk factor for auditory damage, whereas aminoglycosides cause permanent hearing loss due to their damaging effects on hair cells and support structures in the ear. Tinnitus is also associated with the mechanisms of Meniere’s disease, where fluid accumulation in the inner ear disrupts sound response, either by blocking sound transmission or altering electrolyte balance around hair cells.

The societal prevalence of tinnitus is estimated at 15-30%, with 2% experiencing severe symptoms that can lead to suicidal thoughts. While factors like smoking, caffeine, and alcohol consumption show no clear link to tinnitus onset, pregnancy has been associated with an increased risk. Additionally, a strong correlation has been established between tinnitus severity and mental health conditions such as depression, anxiety, and post-traumatic stress disorder.

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Current understanding of tinnitus mechanisms is limited, largely based on theoretical models and modest clinical studies. Research now suggests the auditory nerve pathway plays a critical role in tinnitus development, challenging the previous view that tinnitus was strictly a peripheral auditory issue.

Given the challenges of assessing tinnitus with direct, precise testing, various scales and questionnaires have been created to evaluate the condition. Despite the variety of tools, most remain experimental, and ultimately, clinical decisions rely on physician expertise. Tinnitus treatments have ranged widely, from pharmacological interventions such as ginkgo biloba, betahistine, dexamethasone, lidocaine, and clonazepam to surgical options, auditory behavioral therapies, tinnitus-masking devices, transcranial magnetic stimulation, and psychotherapy.

This study aims to evaluate the effectiveness of clonazepam as a treatment for idiopathic tinnitus or as a means of reducing its impact on patients' quality of life.